Validation of Stability Indicating Method and Degradation Kinetic Study of Apremilast
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منابع مشابه
Validating a Stability Indicating HPLC Method for Kinetic Study of Cetirizine Degradation in Acidic and Oxidative Conditions
A stability indicating High-Performance Liquid Chromatography (HPLC) method wasvalidated and used to study the degradation of cetirizine dihydrochloride in acidic and oxidativeconditions. The separation was carried out on a Symmetry C18 column and a mixture of 50 mMKH2PO4 and acetonitrile (60:40 v/v, pH = 3.5) was used as the mobile phase. The method waslinear over the range of 1-20 μg/mL of ce...
متن کاملValidating a Stability Indicating HPLC Method for Kinetic Study of Cetirizine Degradation in Acidic and Oxidative Conditions
A stability indicating High-Performance Liquid Chromatography (HPLC) method wasvalidated and used to study the degradation of cetirizine dihydrochloride in acidic and oxidativeconditions. The separation was carried out on a Symmetry C18 column and a mixture of 50 mMKH2PO4 and acetonitrile (60:40 v/v, pH = 3.5) was used as the mobile phase. The method waslinear over the range of 1-20 μg/mL of ce...
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High performance liquid chromatography (HPLC) is an integral analytical tool in assessing drug product stability. HPLC methods should be able to separate, detect, and quantify the various drug-related degradants that can form on storage or manufacturing, plus detect and quantify any drug-related impurities that may be introduced during synthesis. Forced degradation studies of new chemical entit...
متن کاملvalidating a stability indicating hplc method for kinetic study of cetirizine degradation in acidic and oxidative conditions
a stability indicating high-performance liquid chromatography (hplc) method wasvalidated and used to study the degradation of cetirizine dihydrochloride in acidic and oxidativeconditions. the separation was carried out on a symmetry c18 column and a mixture of 50 mmkh2po4 and acetonitrile (60:40 v/v, ph = 3.5) was used as the mobile phase. the method waslinear over the range of 1-20 μg/ml of ce...
متن کاملa stability indicating hplc method for determination of mebeverine in the presence of its degradation products and kinetic study of its degradation in oxidative condition
an hplc method for determination of mebeverine hydrochloride (mh) in the presence of its degradation products was developed. the degradation of mh was studied under hydrolysis, oxidative and photolysis stress conditions. under alkaline, acidic and oxidative conditions, degradation of mh was observed. the separation was performed using a symmetry c 18 column and a mixture of 50 mm kh 2 po 4 , ac...
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ژورنال
عنوان ژورنال: Journal of Drug Delivery and Therapeutics
سال: 2020
ISSN: 2250-1177
DOI: 10.22270/jddt.v10i2.3964